To evaluate the effect and safety of intra arterial infusion with Oxaliplatin for previously treated metastatic liver cancer.Eight patients with metastatic liver cancer have received intra arterial 200mg Oxaliplatin once every four weeks.Each case received twice .In these cases,one reached PR;five,NC and two,PD.One case occurred Ⅱ0 leucocytopenia,three showed Ⅰ0~Ⅱ0gastrointestinal side effect,one was found Ⅰ0 hepatic side effect,one appeared Ⅰ0nerval side effect after two courses treatment.No renal damaged. [Conclusion] It's shown that intra arterial infusion with Oxaliplatin is safe and effective.