Nanomedicine–Nanoscale Drugs and Delivery Systems

纳米载体 纳米医学 纳米技术 药物输送 材料科学 纳米材料 生物相容性材料 纳米生物技术 固体脂质纳米粒 纳米纤维 纳米颗粒 生物医学工程 医学
作者
Surya P. Singh
出处
期刊:Journal of Nanoscience and Nanotechnology [American Scientific Publishers]
卷期号:10 (12): 7906-7918 被引量:148
标识
DOI:10.1166/jnn.2010.3617
摘要

Significant progress has been made in nanoscale drugs and delivery systems employing diverse chemical formulations to facilitate the rate of drug delivery and release from the human body. The biocompatible nanomaterials have been used in biological markers, contrast agents for biological imaging, healthcare products, pharmaceuticals, drug-delivery systems as well as in detection, diagnosis and treatment of various types of diseases. Nanomedicines offer delivery of potential drugs to human organs which were previously beyond reach of microscale drugs due to specific biological barriers. The nanoscale systems work as nanocarriers for the delivery of drugs. The nanocarriers are made of biocompatible and biodegradable materials such as synthetic proteins, peptides, lipids, polysaccharides, biodegradable polymers and fibers. This review article reports the recent developments in the field of nanomedicine covering biodegradable polymers, nanoparticles, cyclodextrin, dendrimeres, liposomes and lipid-based nanocarriers, nanofibers, nanowires and carbon nanotubes and their chemical functionalization for distribution to different organs, their solubility, surface, chemical and biological properties, stability and release systems. The toxicity and safety of nanomaterials on human health is also briefly discussed.
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