Study on Inhibitive Effect of Extracts from Cornus officinalis on α-Glucosidase

Objective:To search α-glucosidase inhibitors from Cornus officinalis.Method:All the extracts were extracted by organic solvent and the trace enzyme reaction system was constructed in vitro.Taking PNPG as substrate,acarbose as positive control,and inhibitive effect of extracts from C.officinalis on α-glucosidase was detec-ted.Result:The IC50 value of petroleum ether extracts(38.90 mg·L-1),ethyl acetate extracts(2.40 mg·L-1) and n-butanol extracts(4.26 mg·L-1) were far lower than that of acarbose(1 081.27 mg·L-1) as positive control.Con-clusion:All the extracts of C.officinalis showed a better α-glucosidase inhibitory activity and ethyl acetate extracts showed the strongest inhibitory activity on α-glucosidase.