Objective: To evaluate the indications and effect of non-operative treatment of severe acute pancreatitis.Methods: A retrospective study was carried out on 53 patients with severe acute pancreatitis who underwent conservative treatment from January 1994 to December 2003. Results: The healing rate of Non-operative treatment was 73.6% and the incidence of implication was 43.4% in conservative group, while the healing rate of operative treatment was 60.5% and the incidence of implication was 48.6% in operative treatment group .Conclusions:If Non-operative treatment adopted selectly in severe acute pancreatitis, The effect is satisfactory.