P21 and P53 protein expression in intestinal metaplasia and dysplasia of gastric mucosa

IM To study the relationship between intestinal metaplasia or dysplasia of gastric mucosa and gastric cancer. METHODS P21 and P53 protein expressions were determined in 58 formalinfixed, paraffinembedded specimens of intestinal metaplasia (n=44) and dysplasia of gastric mucosa (n=14) by the SP immunohistochemical method. RESULTS The positive rates of P21 and P53 proteins in type Ⅱb intestinal metaplasia (IM) (700% and 300%) were statistically higher than those in type Ⅰb IM (258% and 64%,P001). The positive rates of P21 and P53 proteins in dysplasia (428% and 285%) were higher than those in IM (34% and 118%). The positive rates of P21 and P53 proteins in dysplasia with type Ⅱb IM (625% and 375%) were significantly higher than those in dysplasia with type Ⅰb IM (166% and 166%).CONCLUSION Dysplasia accompanied by type Ⅱb IM may more easily develop gastric cancer than other lesions.