Anti-A/B antibody titers in group O red blood cell units

Objective: To determine the anti-A/B antibody titers of group O red blood cell units(RBC),and to evaluate the safety and feasibility of urgent transfusion of uncrossmatched group O RBC.Methods: Whole blood was collected from 100 volunteer blood donors and fractionated into RBC and plasma units.The anti-A/B antibody titers in whole blood and RBC of 1-,7-and 14-day storage duration were determined and compared.Results: The IgM anti-A/B antibody titers in most of the whole blood samples were between 4 and 128,and the IgG antibody titers between 16 and 256.Correspondingly,the antibody titers were decreased significantly in most RBC(P0.01),in which IgM antibody titers were between 4 and 32,and IgG antibody titers between 8 and 128.However,no significant changes of antibody titers were observed among the 1-,7-and 14-day RBC.Conclusion: The anti-A/B antibody titer in group O RBC was relatively low,which led to the inference that its urgent use without crossmatching assay might be safe.