Objective To investigate the result of the intra-arterial thrombolysis in posterior-circulation infarction after intravenous thrombolysis.Methods 8 patients with the posterior-circulation infarction within 4-32 hours after the onset of the symptoms were assigned into a superselective intravenous thrombolysis.The symptoms were deteriorared,and they were given intra-arterial thrombolysis.To use by the U.S National of Health Stroke Scale(NIHSS) to assess the improvement of clinical symptoms.Results 5 patiens were improved obviously after intra-arterial thrombolysis.2 patients were improved slightly.1 patient had cerebral hemorrhage.Before intra-arterial thrombolysis and 24 hours,7 days after thrombolysis,the NIHSS score were(31.75±3.20),(22.25±9.22)and(16.5±9.24) score,There were significant differences between them(P0.05).Conclusion The condition of the posterior-circulation infarction was critical,if the result is poor,severe after intravenous thrombolysis,and then arterial thrombolytic therapy was given,the effects is quite satisfactory.