Determination of 15 phthalic acid esters in infant formula milk powder and raw material by gas chromatography-mass spectrometry

Objective To establish a method for determination of phthalic acid esters in infant formula milk powder and raw materials by gas chromatography-mass spectrometry(GC-MS).Methods Samples were extracted with acetonitrile,and then detected by GC-MS.The external standard method was conducted for the quantitative analysis.Results The linear range of 15 phthalic acid esters were 0.001~1 mg/L,except that the linear range of phthalate isononyl ester was 0.01~1 mg/L with R0.99.LOD(S/N=3) and LOQ(S/N=10) were 0.006~0.2 mg/kg and 0.02~0.7 mg/kg,respectively.The recoveries were 88.6%~117.2% at three spiked level with relative standard deviation of 1.0%~9.3%.Conclusion This method is simple,accurate,fast,cheap and stable,and it is suitable for the detection of phthalic acid esters in milk powder.