[Preparation and drug releasing property of curcumin nanoparticles].

To prepare curcumin nanoparticles and evaluate the in vitro release of curcumin.The chitosan-graft-vinyl acetate copolymers were synthesized by free radical polymerization. Curcumin nanoparticles were synthesized by ultrasonic irradiation. The encapsulation efficiency of the nanoparticles and the in vitro release of curcumin were studied.The nanoparticles were discrete and uniform spheres, covered with positive charges. The encapsulation efficiency of nanoparticles was up to 91.6%. The in vitro release profile showed the slower release rate of curcumin.The methods is simple. The nanoparticles possess good physical performance and sustained release character in vitro.