脂质体
结合
化学
药物输送
配体(生物化学)
寡核苷酸
共价键
生物物理学
纳米技术
组合化学
生物化学
材料科学
生物
受体
有机化学
数学分析
数学
DNA
作者
İpek Eroğlu,Mamudu İbrahim
标识
DOI:10.1080/1061186x.2019.1648479
摘要
Early researchers focussed on developing stimuli-responsive liposomes in order to manipulate drug release at the site of action or under certain conditions. In recent times, a great deal of efforts has been made to modify the surface of liposomes with ligands for the purpose of achieving targeted drug delivery. Due to the morphology of liposomes, their surfaces can be engineered by attaching molecules such as oligosaccharides, peptides, antibodies, antigens and oligonucleotides to the bilayer structure. Over the years, a number of techniques including the use of covalent and non-covalent linkages have been utilised in designing ligand–liposome conjugates. In this review, various strategies for the functionalisation of liposomes as well as the different types of ligand–liposome conjugates have been discussed. Finally, the pros and cons of conjugation in liposomes are concisely summarised.
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