Updates of Recent Aortic Aneurysm Research

A ortic aneurysms are defined as a pathological condition characterized by permanent dilation of the aorta that most commonly occurs in the infrarenal and proximal thoracic regions. While generally asymptomatic, progressive aneurysmal dilation is associated with the devastating consequence of aortic rupture. Current therapeutic options to prevent aortic rupture are restricted to surgical repair, with an absence of proven pharmaceutical treatments to prevent progressive growth or rupture. Although surgical treatments have become increasingly sophisticated and less invasive over the previous decade, 1 there remains an urgent need to identify pathways that predispose to aneurysmal formation and to divert treatment from surgical to medical approaches. 2 An improved understanding of the subcellular mechanisms and regulatory networks triggering aneurysm development and subsequent expansion is essential for discovery of novel therapeutic targets. This article highlights recent publications in the journal of Arteriosclerosis, Thrombosis, and Vascular Biology that provide insights into understanding mechanisms and potential therapeutic strategies for aortic aneurysms.