A dual-labeled anti-FAP antibody for imaging and targeted photodynamic therapy of cancer associated fibroblasts in a pancreatic cancer mouse model

Pancreatic ductal adenocarcinoma (PDAC) is dominated by an intense desmoplastic reaction with abundant extra-cellular matrix[1]. This impacts the metabolic and immune tumor microenvironment. Activated cancer associated fibroblasts (CAFs), expressing fibroblast activation protein (FAP), play a role in this desmoplastic reaction [2]. Specific elimination of CAFs in PDAC potentially restores the aberrant tumor microenvironment. Therefore we developed a dual-labeled anti-FAP monoclonal antibody for SPECT imaging and targeted photodynamic therapy (PDT) of CAFs in PDAC.