MSN‐Mediated Sequential Vascular‐to‐Cell Nuclear‐Targeted Drug Delivery for Efficient Tumor Regression

Mesoporous silica nanoparticles functionalized with peptides are developed for sequential drug delivery. The RGD peptide is used for vasculature/cell membrane targeting and the TAT peptide for nuclear targeting. Using this delivery strategy, a tumor in a murine xenograft model is successfully regressed.