载脂蛋白E
创伤性脑损伤
神经科学
医学
等位基因
心理学
内科学
疾病
精神科
生物
遗传学
基因
作者
Narendra Nathoo,Runjan Chetty,James R. van Dellen,Geoffrey Barnett
出处
期刊:Journal of Clinical Pathology-molecular Pathology
[BMJ]
日期:2003-06-01
卷期号:56 (>3): 132-136
被引量:89
摘要
Apolipoprotein E (APOE) is thought to be responsible for the transportation of lipids within the brain, maintaining structural integrity of the microtubule within the neurone, and assisting with neural transmission. Possession of the APOE epsilon4 allele has also been shown to influence neuropathological findings in patients who die from traumatic brain injury, including the accumulation of amyloid beta protein. Previous clinical studies reporting varying outcome severities of traumatic brain injury, including cognitive and functional recovery, all support the notion that APOE epsilon4 allele possession is associated with an unfavourable outcome. Evidence from experimental and clinical brain injury studies confirms that APOE plays an important role in the response of the brain to injury.
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