药物输送
纳米技术
前药
材料科学
超分子化学
聚合物
组合化学
化学
有机化学
分子
生物化学
复合材料
作者
Gleb B. Sukhorukov,Andrey L. Rogach,Bernd Zebli,Tim Liedl,André G. Skirtach,Karen Köhler,A. A. Antipov,Nikolai Gaponik,Andrei S. Susha,Mathias Winterhalter,Wolfgang J. Parak
出处
期刊:Small
[Wiley]
日期:2004-12-28
卷期号:1 (2): 194-200
被引量:280
标识
DOI:10.1002/smll.200400075
摘要
Abstract We present the concept of multifunctional nanoengineered polymer capsules and outline their applications as new drug delivery systems or supramolecular toolboxes containing, for example, enzymes capable of converting nontoxic prodrugs into toxic drugs at a designated location. Such functionalized nanocontainers offer a wide range of applications including enzymatic catalysis, controlled release, and directed drug delivery in medicine due to their multifunctionality. The unique advantage of capsules in comparison to other systems is that they can be functionalized or loaded simultaneously with the above‐mentioned components, thus permitting multifunctional processes in single cells.
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