Copper-catalyzed asymmetric sp3 C–H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst

This report describes a highly enantioselective oxidative sp 3 C–H arylation of N -aryltetrahydroisoquinolines (THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir(ppy) 2 (dtbbpy)]PF 6 , and chiral copper catalysts provide a mild and highly effective sp 3 C–H asymmetric arylation of THIQs.