Copper-catalyzed asymmetric sp3 C–H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst

This report describes a highly enantioselective oxidative sp³ C-H arylation of N-aryltetrahydroisoquinolines (THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir(ppy)₂(dtbbpy)]PF₆, and chiral copper catalysts provide a mild and highly effective sp³ C-H asymmetric arylation of THIQs.