Due to their potential important applications for the separation of protein , the use in biosensors , the development of biomedical diagnostics , the treatment of human diseases and the basic biomedical research , the interaction studies of oligopeptide (3—20 amino acid residues) with synthetic receptors are of great current interest . The recent progress in the interaction studies of synthetic receptor with oligopeptide is reviewed. This review introduces the interaction of small molecule with individual amino acid residue , the sequence selective recognition for oligopeptide of small molecule , the inducement and recognition for oligopeptide of small molecule and the interaction studies of polymer with oligopeptide. In addition , the challenges , as well as the suggestions to further development of the design of oligopeptide receptors are outlined.