灰树花
蘑菇
桑黄
香菇属
保健品
传统医学
灵芝
药用真菌
生物
灵芝
医学
菌丝体
植物
生物化学
多糖
作者
Boris Jakopović,Nada Oršolić,Ivan Jakopovich
出处
期刊:Molecules
[MDPI AG]
日期:2021-11-05
卷期号:26 (21): 6708-6708
被引量:8
标识
DOI:10.3390/molecules26216708
摘要
Medicinal mushrooms are increasingly being recognized as an important therapeutic modality in complementary oncology. Until now, more than 800 mushroom species have been known to possess significant pharmacological properties, of which antitumor and immunomodulatory properties have been the most researched. Besides a number of medicinal mushroom preparations being used as dietary supplements and nutraceuticals, several isolates from mushrooms have been used as official antitumor drugs in clinical settings for several decades. Various proteomic approaches allow for the identification of a large number of differentially regulated proteins serendipitously, thereby providing an important platform for a discovery of new potential therapeutic targets and approaches as well as biomarkers of malignant disease. This review is focused on the current state of proteomic research into antitumor mechanisms of some of the most researched medicinal mushroom species, including Phellinus linteus, Ganoderma lucidum, Auricularia auricula, Agrocybe aegerita, Grifola frondosa, and Lentinus edodes, as whole body extracts or various isolates, as well as of complex extract mixtures.
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