谷胱甘肽
体内
过氧化氢
抗氧化剂
化学
血红素加氧酶
纳米颗粒
羟基自由基
渗透(战争)
体外
肿瘤微环境
免疫系统
生物物理学
癌症研究
材料科学
生物化学
血红素
纳米技术
酶
生物
免疫学
生物技术
工程类
运筹学
作者
Rong Zheng,Yan Cheng,Qi Fan,Yunyun Wu,Xiaoqing Han,Jiao Yan,Haiyuan Zhang
标识
DOI:10.1002/adhm.202100412
摘要
Abstract Chemodynamic therapy (CDT) efficacy has been limited by the poor penetration ability of large nanoparticles (NPs) and the antioxidant activity of tumors, especially high heme oxygenase (HO‐1) and glutathione (GSH) levels. Herein, PEGylated CuMoO x ‐coated and zinc protoporphyrin IX (ZP)‐loaded Cu (CCMZ) NPs are designed to afford rapid degradation ability and augmented CDT efficacy through inhibiting HO‐1 activity and depleting GSH. The deep penetration of tumor can be achieved under the high levels of GSH, which triggers the degradation of CuMoO x shell. Meanwhile, GSH itself is depleted, which converts the reductive environment into constant oxidative environment, thus leading to the degradation of Cu core. Furthermore, the release of ZP from CCMZ NPs can inhibit HO‐1 activity and provide a favorable microenvironment for CDT, and the release of Cu and Mo ions can convert hydrogen peroxide into hydroxyl radical to eliminate tumor cells more efficiently. In addition, CCMZ NPs also play an immune vaccine‐like effect to recruit different immune cells for antitumor immunotherapy. In vitro and in vivo studies prove the augmented CDT property of CCMZ NPs, supplying a new strategy for improving CDT efficacy.
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