滋养层
间质细胞
免疫耐受
巨噬细胞
串扰
细胞生物学
巨噬细胞极化
怀孕
生物
医学
免疫系统
胎盘
胎儿
先天免疫系统
免疫学
胎盘形成
作者
Jinli Ding,Yan Zhang,Xiaopeng Cai,Lianghui Diao,Chaogang Yang,Jing Yang
标识
DOI:10.3389/fimmu.2021.758281
摘要
The immune tolerance microenvironment is crucial for the establishment and maintenance of pregnancy at the maternal-fetal interface. The maternal-fetal interface is a complex system containing various cells, including lymphocytes, decidual stromal cells, and trophoblasts. Macrophages are the second-largest leukocytes at the maternal-fetal interface, which has been demonstrated to play essential roles in remodeling spiral arteries, maintaining maternal-fetal immune tolerance, and regulating trophoblast's biological behaviors. Many researchers, including us, have conducted a series of studies on the crosstalk between macrophages and trophoblasts at the maternal-fetal interface: on the one hand, macrophages can affect the invasion and migration of trophoblasts; on the other hand, trophoblasts can regulate macrophage polarization and influence the state of the maternal-fetal immune microenvironment. In this review, we systemically introduce the functions of macrophages and trophoblasts and the cell-cell interaction between them for the establishment and maintenance of pregnancy. Advances in this area will further accelerate the basic research and clinical translation of reproductive medicine.
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