分子成像
超声波
正电子发射断层摄影术
临床前影像学
扫描仪
生物医学工程
断层摄影术
计算机科学
功能成像
医学物理学
核医学
放射科
医学
人工智能
体内
生物
生物技术
作者
Jean Provost,Anikitos Garofalakis,Joevin Sourdon,Damien Bouda,Béatrice Berthon,Thomas Viel,Mailyn Pérez-Liva,Charlotte Lussey‐Lepoutre,Judith Favier,Mafalda Correia,Mathieu Pernot,Johanna Chiche,Jacques Pouysségur,Mickaël Tanter,Bertrand Tavitian
标识
DOI:10.1038/s41551-018-0188-z
摘要
Positron emission tomography–computed tomography (PET–CT) is the most sensitive molecular imaging modality, but it does not easily allow for rapid temporal acquisition. Ultrafast ultrasound imaging (UUI)—a recently introduced technology based on ultrasonic holography—leverages frame rates of up to several thousand images per second to quantitatively map, at high resolution, haemodynamic, biomechanical, electrophysiological and structural parameters. Here, we describe a pre-clinical scanner that registers PET–CT and UUI volumes acquired simultaneously and offers multiple combinations for imaging. We demonstrate that PET–CT–UUI allows for simultaneous images of the vasculature and metabolism during tumour growth in mice and rats, as well as for synchronized multi-modal cardiac cine-loops. Combined anatomical, functional and molecular imaging with PET–CT–UUI represents a high-performance and clinically translatable technology for biomedical research. A system that combines positron emission tomography, computed tomography and ultrafast ultrasound allows for simultaneous multi-parametric imaging in animal models.
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