静电纺丝
再生医学
药物输送
纳米技术
纳米纤维
组织工程
3D打印
材料科学
生物医学工程
再生(生物学)
医学
干细胞
聚合物
生物
细胞生物学
复合材料
遗传学
作者
Shixuan Chen,Ruiquan Li,Xiaoran Li,Jingwei Xie
标识
DOI:10.1016/j.addr.2018.05.001
摘要
Electrospinning provides an enabling nanotechnology platform for generating a rich variety of novel structured materials in many biomedical applications including drug delivery, biosensing, tissue engineering, and regenerative medicine. In this review article, we begin with a thorough discussion on the method of producing 1D, 2D, and 3D electrospun nanofiber materials. In particular, we emphasize on how the 3D printing technology can contribute to the improvement of traditional electrospinning technology for the fabrication of 3D electrospun nanofiber materials as drug delivery devices/implants, scaffolds or living tissue constructs. We then highlight several notable examples of electrospun nanofiber materials in specific biomedical applications including cancer therapy, guiding cellular responses, engineering in vitro 3D tissue models, and tissue regeneration. Finally, we finish with conclusions and future perspectives of electrospun nanofiber materials for drug delivery and regenerative medicine.
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