[Single center retrospective study of 184 children with inflammatory bowel disease seen from 2000-2014].

Objective: To investigate the clinical data of children with inflammatory bowel disease (IBD) retrospectively, including Crohn's disease (CD) and ulcerative colitis (UC) and identify the clinical characteristics and trends of change. Method: Clinical data of hospitalized patients diagnosed as IBD in Beijing Children's Hospital from January 2000 to December 2014 were collected and retrospectively analyzed. Patients were divided into six groups based on type of disease and year of admission: Group A1(CD, 2000-2004) included 12 patients, Group B1(CD, 2005-2009) included 11, Group C1(CD, 2010-2014) included 51; Group A2(UC, 2000-2004) included 17, Group B2(UC, 2005-2009) included 25, Group C2(UC, 2010-2014) included 68. Result: A total of 184 IBD patients were included in the study, 74 had CD and 110 had UC. The hospitalization constituent ratio of CD increased from 0.6/10 000 in Year 2000 to 2.9/10 000 in Year 2014. The hospitalization constituent ratio of UC increased from 0.5/10 000 in Year 2001 to 3.9/10 000 in Year 2014. The hospitalization constituent ratios of CD and UC both increased gradually(P<0.05). Up to 61.4%(113/184) of IBD patients belong to early onset IBD, furthermore the very early onset IBD and infantile IBD accounted for 41.8%(77/184) and 26.6%(49/184) respectively. For CD, ileocolonic type(47.3%, 35/74) and non-structuring, non-penetrating type (67.6%, 50/74) were more common. Perianal disease occured in 31.1%(23/74) of CD patients; 81.1%(60/74) of CD patients had moderate/severe activity. For UC, pancolitis type(59.1%, 65/110) was more common. There were no significant changes for location of pathological change, disease behavior, activity degree of CD, extent of UC lesion and incidence of surgery, intestinal perforation and hemorrhage of gastrointestinal tract for IBD in the past 15 years(P>0.05). Severe UC(S3) was more common in Group A2(64.7%, 11/17), but moderate UC(S2) was more common in Group C2(48.5%, 33/68), the difference was statistically significant (P=0.001 7). Conclusion: During the past 15 years, the hospitalization constituent ratio for IBD in our hospital showed a growing trend. The ratio of infantile IBD and very early onset IBD was high. For CD, perianal disease was commonly seen and most patients had moderate/severe activity. The surgery rate and incidence of intestinal obstruction and perforation were higher in the CD patients than UC patients. For UC, the lesions were more extensively combined with higher disease activity.目的： 总结炎性肠病(IBD)患儿的临床资料，包括克罗恩病(CD)和溃疡性结肠炎(UC)，分析其临床特点及变化趋势。 方法： 对2000年1月1日至2014年12月31日在北京儿童医院确诊的184例IBD住院患儿的临床资料进行回顾性分析，按照入院时间及疾病种类分为6组：A1组(CD，2000年1月1日—2004年12月31日)12例，B1组(CD，2005年1月1日—2009年12月31日)11例，C1组(CD，2010年1月1日—2014年12月31日)51例；A2组(UC，2000年1月1日—2004年12月31日)17例，B2组(UC，2005年1月1日—2009年12月31日)25例，C2组(UC，2010年1月1日—2014年12月31日)68例。分析比较6组IBD患儿的临床特点及变化。 结果： 184例IBD患儿中，CD 74例，UC 110例。CD的入院构成比从2000年的0.6/10 000上升至2014年的2.9/10 000；UC的入院构成比从2001年的0.5/10 000升至2014年的3.9/10 000，CD和UC的入院构成比呈逐渐上升的趋势(P＝0.000 5和0.004 9)。61.4%(113/184)的IBD患儿属于早发IBD，极早发IBD和婴儿型IBD分别占41.8%(77/184)、26.6%(49/184)。CD患儿以回结肠型(47.3%，35/74)及非狭窄非穿透型(67.6%，50/74)为主，并且有31.1%(23/74)的患儿合并肛周病变，疾病活动程度以中－重度活动(81.1%，60/74)为主；UC患儿以广泛结肠型(59.1%，65/110)为主。A2组疾病活动程度以重度活动为主(64.7%，11/17)，C2组以中度活动为主(48.5%，33/68)，差异有统计学意义(P＝0.002，P<0.001 7)。 结论： 15年内北京儿童医院IBD患儿的入院构成比呈逐渐增加的趋势。婴儿型IBD及极早发IBD患儿所占比例较高。CD合并肛周病变常见且以中－重度活动为主，其手术率、肠梗阻、肠穿孔的发生率均明显高于UC患儿。UC病变范围广泛且疾病活动程度重。.