Tailoring Ga Flexible Single-Atom Nanozymes for Self-Adaptive Catalytic Performance through Multienzyme Activity Switching

Inorganic nanozymes remain limited by rigid active-center structures, lacking the adaptive flexibility of natural enzymes. Here we report a flexible single-atom nanozyme (FSAzyme) enabled by regulation of Ga coordination. A dynamically reconstructing Ga–N 3 S site exhibits self-adaptive electronic modulation, allowing the FSAzyme to realize multiple enzyme-mimicking activities and versatile sensing functions. These results establish a general design strategy to introduce enzyme-like adaptivity into single-atom nanozymes.