Reframing APS thrombogenesis: a new PF4-driven mechanism

In this issue of Blood, Field et al 1 show that platelet factor 4 (PF4) forms a trimolecular antigenic complex with β2-glycoprotein I (β2GP1) and neutrophil extracellular traps (NETs), amplifying antiphospholipid syndrome (APS) autoantibody recognition and promoting thrombosis.