Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy

Our data suggest that THM exerts its anticancer potential by inducing TRIM38-dependent PANoptosis and it also has synergistic antitumor effects in combination with conventional anticancer strategies. THM will be a promising candidate drug used alone or in combination with other anticancer regimens for cancer treatment.