Optimized Lipid Nanoparticles for Co‐Delivery of mRNA and siRNA Therapeutics in Refractory Liver Cancer

-s LNPs, functionalized with lactobionic acid for selective HCC targeting, enable efficient co-delivery of p53 mRNA and Nrf2 siRNA. This strategy restores ferroptosis and induces apoptosis in sorafenib-resistant HCC by suppressing SLC7A11, leading to marked tumor inhibition. Our study demonstrates an ML-assisted LNP optimization strategy, advancing precision RNA therapeutics to overcome resistance in refractory liver cancer.