先天免疫系统
免疫学
获得性免疫系统
特应性皮炎
生物
免疫系统
模式识别受体
先天性淋巴细胞
树突状细胞
免疫
Toll样受体
神经科学
作者
Natalija Novak,Susanne Koch,Jean‐Pierre Allam,Thomas Bieber
标识
DOI:10.1016/j.jaci.2009.11.019
摘要
Much knowledge has been gained about the multifaceted functions of dendritic cells (DCs). The central role of various DC subtypes as bridges between innate and adaptive immunity has become more and more evident. However, a high number of differences exist in the expression of pattern-recognition receptors, the first sensors of the innate immune system, in particular Toll-like receptors (TLRs) by distinct DC subtypes (including myeloid and plasmacytoid DCs), their maturation stage, and tissue distribution, as well as state of health or disease. Furthermore, a plethora of variations in human and murine model systems have to be considered. This review sheds some light on this complex and rapidly growing field. It summarizes the most recent findings and deals with the role of TLR-expressing DCs as promoters of chronic inflammatory immune responses in patients with atopic dermatitis, as well as tolerogenic pathways. Therefore TLR-bearing DCs represent promising targets, which might help to improve tolerance induction during immunotherapeutic approaches in the future.
科研通智能强力驱动
Strongly Powered by AbleSci AI