自愈水凝胶
羧甲基纤维素
化学
生物利用度
胰岛素
口服
甲基纤维素
多糖
高分子化学
纤维素
生物化学
药理学
医学
内科学
有机化学
钠
作者
Xiaoye Gao,Yue Cao,Xiaolan Song,Zhe Zhang,Xiuli Zhuang,Chaoliang He,Xuesi Chen
标识
DOI:10.1002/mabi.201300384
摘要
Biodegradable and pH-responsive carboxymethyl cellulose/poly(acrylic acid) hybrid hydrogels are synthesized. The hydrogels deswell in acidic artificial gastric fluid (AGF) but rapidly swell in neutral artificial intestinal fluid (AIF), rendering selective enzymatic degradation of the gels as well as accelerated drug release from insulin-loaded hydrogels in AIF. Oral administration of insulin-loaded hydrogels to streptozotocin-induced diabetic rats leads to a continuous decline in the fasting blood glucose level within 6 h post-administration, and the relative pharmacological availability increases more than 10 times compared to oral administration of free insulin solution. The relative bioavailability of hydrogel-encapsulated insulin after oral administration to healthy rabbits is 6.6%.
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