The expression of leucocyte CD64 、CD16 in cord blood

Objective:To study the expression of leucocyte CD64、CD16 in cord blood and its possible reason.Methods:The expressions of CD64、CD16 on neutrophils、lymphocytes and monocytes in cord blood from twenty normal neonates were investigated by flow cytometry.Meanwhile the whole blood samples from thirties adults were also studied.All statistical analyses were done with SPSS10.0.Results:The expressions of CD64 on neutrophils in cord blood(171.913±87.01) were significantly higher than that of in adult controls(98.05±44.92)(P0.01),while the expressions of CD16(939.12±140.61)were significantly lower than that of in controls(1269.44±107.35)(P0.01).The cord lymphocytes expressed only a small amount of CD64(37.37±4.88)、CD16(84.42±51.23)as adult lymphocytes(35.72±6.9)、(81.07±50.11),no obvious difference between two groups(P0.05).The expressions of CD64 on monocytes in cord blood(291.08±118.91)were also the same as adult′s monocytes(256.61±143.02)(P0.05),but the expressions of CD16(67.99±19.46) were significantly higher than that of in adult controls(49.60±17.75)(P0.01).Conclusion:neonatal granulocytes expressed significantly higher levels of CD64 but significantly lower levels of CD16.