Research Progress in Mitochondrial Apoptosis Pathway

Mitochondria plays an important role in the energy metabolism of cell. However,the mitochondrial important function in death pathway was not recognized until the mid-1990s. Some mitochondrial associated proteins,such as proapoptotic factors,cytochrome c,apoptosis-inducing factor,second mitochondriaderived activator of caspases,high-temperature requirement A2,endonuclease G play important roles in the process of apoptosis. Here is to make a review mainly focusing on the role of mitochondria in mammalian cell death.