Objective To explore the feasibility and safety of LC combined with intraoperative ERCP for the onestage treatment of gallbladder stone with choledocholithiasis.Methods Thirty-six patients with gallbladder stone and choledocholithiasis were treated with the combined procedures and the operation,postoperative recovery,hospital stay,and complications were retrospectively analysed.Results 10 of 31 patients with preoperative diagnosed choledocholithiasis were successfully treated by ERCP at first,then underwent LC.Other 21 patients and 5 patients with suspected choledocholithiasis comfirmed by TCC were treated by LC at first,then underwent ERCP.ERCP was performed successfully in 35 cases(97.22%).5 patients had postoperative hyperamylasemia temporarily,no other complications occurred.Mean postoperative hospitalization was 4 days.Conclusion Combined LC/ERCP can be performed safely,and there are advantages including onestage treatment,avoidance of unnecessary preoperative ERCP,and eliminating the need to return to the operation as the failure of postoperative ERCP.