To Evaluate The Effectiveness Of Different Criteria For Slavage Liver Transplantation For Hepatocellular Carcinoma Recurrence After Liver Resection

Objective To evaluate the clinical effectiveness of Milan Criteria,UCSF Criteria,Up-to-seven Criteria for salvage liver transplantation(SLT) for hepatocellular carcinoma(HCC) recurrence after liver resection.Methods From June 1999to June 2011,a total of 724 adult patients with HCC underwent orthotopic liver transplantation.Among these patients,617 underwent primary liver transplantation(PLT),while the other 107 patients underwent SLT after primary liver curative resection due to intrahepatic recurrence.Statistically analyse the difference and the consistency of survival rate after liver transplantation between the PLT and SLT group,according to Milan Criteria,UCSF Criteria,Up-to-seven Criteria.Results For the patients underwent PLT,Milan Criteria,UCSF Criteria,Up-to-seven Criteria show the consistency to evaluate the long-term survival after liver transplantation,with the 5-year survival rate 76.2%,75.5%,73.4%.For SLT patients,Milan Criteria,UCSF Criteria show the consistency to evaluate the long-term survival after liver transplantation,with the 5-year survival rate 83.1%,72.6%.The 5-year survival rate is only 49.9% meeting Upto-seven Criteria,which is 49.4% beyond this criteria,with no effectiveness.Conclusions Milan Criteria,UCSF Criteria show effective consistency for selection of Salvage liver transplantation for HCC recurrence after liver resection,while Up-to-seven criteria do not.For SLT,a three-dimensional variables model should be collected to overall evaluate the prognosis of SLT,including HCC data of primary liver resection and before SLT for HCC recurrence,and also the interval term from primary liver resection to HCC recurrence.