Immunologic mechanisms underlying sepsis

Sepsis remains the leading cause of death in intensive care unit.The pathogenesis of sepsis is extremely complex. Immune dysfunction plays an important role in the occurrence and development of sepsis. Many mechanisms are responsible for sepsis induced immune-suppression, including apoptotic depletion of immune cells, increased T regulatory and myeloid-derived suppressor cells, and cellular exhaustion. The article provided a brief review on the advance of immunologic mechanisms underlying sepsis. Key words: Sepsis; Immune