隐形眼镜
镜头(地质)
无线
生物相容性
计算机科学
生物医学工程
医学
材料科学
物理
眼科
电信
光学
冶金
作者
Minjae Ku,Joohee Kim,Jong‐Eun Won,Wonkyu Kang,Young Geun Park,Jihun Park,Jae Hyun Lee,Jinwoo Cheon,Hyun Ho Lee
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2020-07-10
卷期号:6 (28)
被引量:159
标识
DOI:10.1126/sciadv.abb2891
摘要
Despite various approaches to immunoassay and chromatography for monitoring cortisol concentrations, conventional methods require bulky external equipment, which limits their use as mobile health care systems. Here, we describe a human pilot trial of a soft, smart contact lens for real-time detection of the cortisol concentration in tears using a smartphone. A cortisol sensor formed using a graphene field-effect transistor can measure cortisol concentration with a detection limit of 10 pg/ml, which is low enough to detect the cortisol concentration in human tears. In addition, this soft contact lens only requires the integration of this cortisol sensor with transparent antennas and wireless communication circuits to make a smartphone the only device needed to operate the lens remotely without obstructing the wearer's view. Furthermore, in vivo tests using live rabbits and the human pilot experiment confirmed the good biocompatibility and reliability of this lens as a noninvasive, mobile health care solution.
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