肾细胞癌
医学
肾
微生物群
泌尿系统
肾切除术
发病机制
癌症
肾癌
癌
病理
内科学
泌尿科
胃肠病学
生物
生物信息学
作者
Stefan Heidler,Lukas Lusuardi,Stephan Madersbacher,Christa Freibauer
出处
期刊:Urologia Internationalis
[S. Karger AG]
日期:2019-11-12
卷期号:104 (3-4): 247-252
被引量:18
摘要
<b><i>Introduction:</i></b> The renal bacterial colonization has not been explored so far. <b><i>Objective:</i></b> The aim of this study was to describe the renal microbiome and to determine differences of the renal microbiome in healthy and tumor-bearing parenchyma. <b><i>Methods:</i></b> Ten biopsies from patients undergoing laparoscopic nephrectomy for renal carcinoma with no history of urinary tract infections within the last 6 months were included in this study. The identification of all microorganisms was done using 16S DNA sequencing. The beta diversity analysis was performed by Bray-Curtis dissimilarity. <b><i>Results:</i></b> In all kidney samples, a plethora of microorganisms was found, with significant differences between benign and malignant renal tissue (<i>p</i> < 0.0001). <b><i>Conclusions:</i></b> There is evidence that healthy kidney tissue as well as renal cell cancer tissue have a specific microbiome, thus opening new perspectives in renal physiology and tumor pathogenesis.
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