AUTOPHAGY IN THE HTR-8/SVNEO CELL OXIDATIVE STRESS MODEL IS ASSOCIATED WITH NLRP1 INFLAMMASOME ACTIVATION

Based on the establishment of an in vitro model of trophoblast oxidative damage in human placental trophoblast cell HTR-8/SVneo, this study investigated whether there were activation of NLRP1 inflammasomes and excessive autophagy in oxidative stress damage. And further demonstrate whether there is a cascade relationship between the activation of NLRP1 inflammasomes and the phenomenon of excessive autophagy.