The Combretaceae family consists of 600 species of trees, shrubs and lianas in about 18-20 genera. Plants belonging to this family are found in tropical and subtropical regions, mostly in Africa and India. Combretum and Terminalia are the largest and most widespread genus of Combretaceae. Species of Combretaceae family are reported for treating many diseases and have important secondary metabolites with antioxidant activities. This review focuses on 11 medicinal plants, 9 phytochemical containing plants and 33 plants having antioxidant activity.