生物粘附
聚丙烯酸
粘附
组织粘连
材料科学
胶粘剂
聚合物
纳米技术
密封剂
生物医学工程
复合材料
图层(电子)
医学
作者
Xin Peng,Xianfeng Xia,Xiayi Xu,Xuefeng Yang,Boguang Yang,Pengchao Zhao,Weihao Yuan,Philip Wai Yan Chiu,Liming Bian
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2021-06-04
卷期号:7 (23)
被引量:131
标识
DOI:10.1126/sciadv.abe8739
摘要
Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical demand because of the interfering interfacial water and limited adhesive-tissue interactions. Here we report a self-gelling and adhesive polyethyleneimine and polyacrylic acid (PEI/PAA) powder, which can absorb interfacial water to form a physically cross-linked hydrogel in situ within 2 seconds due to strong physical interactions between the polymers. Furthermore, the physically cross-linked polymers can diffuse into the substrate polymeric network to enhance wet adhesion. Superficial deposition of PEI/PAA powder can effectively seal damaged porcine stomach and intestine despite excessive mechanical challenges and tissue surface irregularities. We further demonstrate PEI/PAA powder as an effective sealant to enhance the treatment outcomes of gastric perforation in a rat model. The strong wet adhesion, excellent cytocompatibility, adaptability to fit complex sites, and easy synthesis of PEI/PAA powder make it a promising bioadhesive for numerous biomedical applications.
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