多发性硬化
临床孤立综合征
医学
病因学
小RNA
内科学
脱髓鞘病
肿瘤科
麦当劳标准
扩大残疾状况量表
疾病
免疫学
胃肠病学
基因
生物
遗传学
作者
Furkan Sarıdaş,Havva Tezcan Ünlü,Gülşah Çeçener,Ünal Egelí,Maryam Sabour Takanlou,Leila Sabour Takanlou,Berrin Tunca,Mehmet Zarifoğlu,Ömer Faruk Turan,Özlem Taşkapılıoğlu
标识
DOI:10.1080/01616412.2021.1975221
摘要
Multiple sclerosis (MS) is an inflammatory, autoimmune demyelinating, and neurodegenerative disorder of the central nervous system. Interactions between environmental factors, predisposition genes, and determining genes appear to be involved in its etiology. Epigenetic mechanisms such as microRNA-mediated gene regulation can determine the susceptibility and severity of autoimmune diseases. Therefore, to determine the role of miR-146a and miR-155 in MS and its developmental stages, the expression levels in the serum of MS and clinically isolated syndrome (CIS) patients were compared with those of healthy controls. In the present study, the expression levels of miR-146a and miR-155 were assessed using quantitative Real-Time PCR in blood samples of 15 CIS patients and 61 relapsing-remitting multiple sclerosis (RRMS) patients alongside 32 healthy patients as controls. Furthermore, any associations with the clinicopathologic variables of the patients were also evaluated. Dysregulations were found only in the miR-146a and miR-155 expressions in the RRMS-Control group. When the RRMS patients were evaluated in terms of the characteristics of sex, annual attack rate, age of diagnosis, duration of follow-up, and immunomodulatory treatments used, no significant differences were observed. However, significant dysregulations were identified in miRNA expression in the vitamin D level, EDSS values, and the number of attacks. ROC curve analysis showed that miR-146a and miR-155 were significant in the RRMS-Control group for the area under the curve (AUC). It is possible that miR-146a may be associated with vitamin D deficiency and disease disability, while miR-155 may be associated with the number of attacks.
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