生物
衣壳
定制
骨骼肌
细胞生物学
病毒学
基因
计算生物学
基因组编辑
解剖
遗传学
清脆的
政治学
法学
出处
期刊：Cell
[Cell Press]
日期：2021-09-16
卷期号：184 (19): 4845-4847
被引量：2
标识
DOI：10.1016/j.cell.2021.08.031
摘要
Directed evolution of AAV capsids has been a successful strategy for generating bespoke serotypes to target gene therapies more specifically to the intended tissue. This has now been achieved for the largest organ, skeletal muscle, by selecting for an RGD containing integrin binding heptamer in a hypervariable region of the capsid of AAV9.
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