免疫原性
获得性免疫系统
免疫系统
免疫学
先天免疫系统
生物
免疫
医学
计算生物学
作者
Sivan Cohen,Shan Chung
出处
期刊:Bioanalysis
[Future Science Ltd]
日期:2021-06-14
卷期号:13 (13): 1071-1081
被引量:12
标识
DOI:10.4155/bio-2021-0077
摘要
assays with human innate and adaptive immune cells are commonly used alternatives that can reveal cell-mediated unwanted immune responses. Multiple methods have been developed to assess the immune cell response following exposure to biotherapeutics and estimate the potential immunogenicity of biotherapeutics. This review highlights the role of innate and adaptive immune cells as the drivers of immunogenicity and summarizes the use of these cells in assays to predict clinical ADA.
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