Nuclear magnetic resonance spectroscopy is an absorption spectroscopic technique that helps in structural elucidation and has a wide range of applications in various fields like drug discovery and development, metabolomics, combinatorial chemistry, and food sciences.This paper gives information about nuclear magnetic resonance spectroscopy, and clear description of LC-NMR-MS, and a brief description of other hyphenations with NMR like HPLC-NMR, GC-NMR, GPC-NMR, SEC-NMR, SFC-NMR, SFE-NMR, CE-NMR, SPE-NMR, CEC-NMR, and their applications.