香豆素
化学
传统医学
药理学
立体化学
组合化学
医学
有机化学
作者
Hui Xu,Zili Ren,Min Lv
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2022-09-01
卷期号:22 (16): 2124-2137
被引量:9
标识
DOI:10.2174/1389557522666220214101231
摘要
Abstract: Osthole, a naturally occurring coumarin-type compound, is isolated from the Chinese herbal medicine Cnidium monnieri (L.) and exhibits a broad range of biological properties. In this review, the total synthesis and structural modifications of osthole and its analogs are described. Additionally, the progress on bioactivities of osthole and its analogs has been outlined since 2016. Moreover, the structure-activity relationships and mechanisms of action of osthole and its derivatives are discussed. These can provide references for future design, development, and application of osthole and its analogs as drugs or pesticides in the fields of medicine and agriculture.
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