染色质
长寿
染色质重塑
转录因子
生物
XBP1型
转录调控
老化
细胞生物学
遗传学
基因
RNA剪接
核糖核酸
作者
Guillermo Martínez-Corrales,Mengjia Li,Tatiana Svermova,Alex Augusto Gonçalves,Diana Voicu,A. Dobson,Tony D. Southall,Nazif Alic
出处
期刊:Nature Aging
日期:2022-12-01
卷期号:2 (12): 1176-1190
被引量:1
标识
DOI:10.1038/s43587-022-00312-x
摘要
A transient, homeostatic transcriptional response can result in transcriptional memory, programming subsequent transcriptional outputs. Transcriptional memory has great but unappreciated potential to alter animal ageing as animals encounter a multitude of diverse stimuli throughout their lifespan. Here we show that activating an evolutionarily conserved, longevity-promoting transcription factor, dFOXO, solely in early adulthood of female fruit flies is sufficient to improve their subsequent health and survival in mid- and late life. This youth-restricted dFOXO activation causes persistent changes to chromatin landscape in the fat body and requires chromatin remodellers such as the SWI/SNF and ISWI complexes to program health and longevity. Chromatin remodelling is accompanied by a long-lasting transcriptional programme that is distinct from that observed during acute dFOXO activation and includes induction of Xbp1. We show that this later-life induction of Xbp1 is sufficient to curtail later-life mortality. Our study demonstrates that transcriptional memory can profoundly alter how animals age.
科研通智能强力驱动
Strongly Powered by AbleSci AI