化学
铱
对映选择合成
产量(工程)
催化作用
表面改性
炔烃
组合化学
有机化学
药物化学
物理化学
材料科学
冶金
作者
Su-Jia Zhouqian,Si‐Yong Yin,Dong‐Song Zheng,Wen Zhang,Suzhen Zhang,Qianqun Gu,Shu‐Li You
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2023-01-29
卷期号:34 (12): 1442-1446
被引量:7
摘要
Abstract Ir(I)-catalyzed atroposelective hydroarylation of alkynes with 1-arylisoquinolines through C–H functionalization was realized. In the presence of 5 mol% of [Ir(cod)Cl]2 and 10 mol% of QUINOX-P, a wide range of axially chiral alkenylated biaryls were obtained in up to 98% yield and 97% ee. Notably, only one equivalent of the alkyne was required to guarantee a high efficiency of this C–H functionalization process. This reaction exhibits excellent functional-group tolerance under mild conditions.
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