细胞毒性
抗菌剂
海绵
化学
两亲性
立体化学
生物活性
多胺
生物化学
金黄色葡萄球菌
拉伤
生物
细菌
体外
有机化学
植物
遗传学
解剖
共聚物
聚合物
作者
Tanja M. Voser,Joshua B. Hayton,Dale W. Prebble,Ju Jin,Gary Grant,Merrick Ekins,Anthony Richard Carroll
标识
DOI:10.1021/acs.jnatprod.2c01125
摘要
Bioassay-guided investigation of the sponge Aaptos lobata resulted in the isolation and identification of two new amphiphilic polyamines, aaptolobamines A (1) and B (2). Their structures were determined through analysis of NMR and MS data. MS analysis also indicated that A. lobata contained a complex mixture of aaptolobamine homologues. Both aaptolobamines A (1) and B (2) show broad bioactivity, including cytotoxicity against cancer cell lines, moderate antimicrobial activity against a methicillin-resistant strain of Staphylococcus aureus, and weak activity against a Pseudomonas aeruginosa strain. The mixtures of aaptolobamine homologues were shown to contain compounds that bind to the Parkinson’s disease associated amyloid protein α-synuclein and inhibit its aggregation.
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