化学
立体中心
催化作用
对映选择合成
有机催化
组合化学
功能群
立体化学
有机化学
聚合物
作者
Fengbiao Luo,Hui Dong,Weiwu Ren,Yang Wang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-10-17
卷期号:24 (42): 7727-7731
被引量:4
标识
DOI:10.1021/acs.orglett.2c02874
摘要
The asymmetric catalytic [4 + 2] cycloannulation of ortho-aminophenyl p-QMs with different types of alkenes for the construction of tetrahydroquinolines containing three contiguous stereogenic centers was developed. This is the first example of catalytic asymmetric cycloannulation of ortho-aminophenyl p-QMs. This reaction exhibits excellent functional group tolerance. Excellent yields, exclusive diastereoselectivities, and high enantioselectivities were obtained in this efficient organocatalytic reaction.
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