厌氧糖酵解
骨肉瘤
糖酵解
癌症研究
肿瘤进展
瓦博格效应
生物
下调和上调
新陈代谢
生物化学
基因
作者
Yiping Weng,Weihao Duan,Xuecheng Yu,Furen Wu,Daibin Yang,Yuqing Jiang,Jingbin Wu,Muyi Wang,Xin Wang,Yifei Shen,Yunkun Zhang,Hua Xu
摘要
Osteosarcoma (OS) is the most common primary malignant neoplasm of the bone. Recent studies have indicated that the inhibitory effects of miR-324-3p could affect the development of numerous cancers. However, its biological roles and underlying mechanisms in OS progression remain unexplored. In this study, miR-324-3p expression was markedly reduced in OS cell lines and tissues. Functionally, miR-324-3p overexpression suppressed OS progression and was involved in the Warburg effect. Mechanistically, miR-324-3p negatively regulated phosphoglycerate mutase 1 (PGAM1) expression by targeting its 3'UTR. Moreover, high expression of PGAM1 promoted OS progression and aerobic glycolysis, which were associated with inferior overall survival in patients with OS. Notably, the tumor suppressor functions of miR-324-3p were partially recovered by PGAM1 overexpression. In summary, the miR-324-3p/PGAM1 axis plays an important role in regulating OS progression by controlling the Warburg effect. Our results provide mechanistic insights into the function of miR-324-3p in glucose metabolism and subsequently on the progression of OS. Targeting the miR-324-3p/PGAM1 axis may be a promising molecular strategy for the treatment of OS.
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