多米诺骨牌
化学
吲哚试验
对映选择合成
组合化学
催化作用
基质(水族馆)
手性(物理)
范围(计算机科学)
功能群
轴对称性
有机化学
计算机科学
手征对称破缺
数学
海洋学
物理
聚合物
几何学
量子力学
夸克
Nambu–Jona Lasinio模型
程序设计语言
地质学
作者
Junwei Ye,Qingwei Song,David Z. Pan,Zhongyi Zeng,Hui Gao,Huiying Xu,Wen‐Bin Yi,Zhi Zhou
标识
DOI:10.1002/adsc.202301302
摘要
Abstract We report herein a chiral Cp X Rh(III)‐catalyzed domino cyclization/C 3 ‐arylation process using 2‐alkynylanilines and 1‐diazonaphthoquinones as viable substrates, delivering indole‐based derivatives endowed with axial chirality. The method features high enantioselectivity, broad substrate scope, and robust functional group tolerance. Subsequent functionalization of the synthesized scaffolds underlines the practicality of this approach in the design of indole‐derivated axially chiral frameworks, demonstrating its substantial promise in synthetic and medicinal chemistry applications.
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